Pentedrone (also known as Drone) is a synthetic stimulant


Pentedrone (also known as Drone) is a synthetic stimulant substance of the substituted cathinone chemical class that produces typical cathinone-type stimulating and euphoric effects when administered. Its stimulant effects are believed to be caused by its activity as an NDRI (norepinephrine-dopamine reuptake inhibitor), with modest effects on serotonin reuptake.

Pentedrone was first detected being sold on the research chemical market during 2010 by the European Monitoring Centre for Drugs and Drug Addiction (i.e. EMCDDA). It is an example of a contemporary designer drug specifically chosen to mimic and/or replace the functional and structural features of popular street drugs like cocaine, MDMA, or methamphetamine, which are sometimes imprecisely referred to as “bath salts”

Pentedrone is known to come in the form of either a white powder or crystallized shardswhich users can ingest to produce a powerful, fast-acting but short-lived euphoric stimulant effects which are comparable to those of crack-cocaine, N-ethylpentedrone and a-PVP-type compounds, particularly when they are insufflated, vaporized or injected.Starting with the advent of MDPV, research chemical stimulants like pentedrone have gained notoriety for its tendency to induce compulsive redosing and addictive behaviors in a seemingly significant percentage of its users as well the ability to readily induce paranoid, delusional states and stimulant psychosis when misused or taken in excess.

Little research exists about both pentedrone particularly with regards to its toxicity, addiction and abuse potential in humans. Due to its novelty and brief history of human usage, all information related to the use of this compound should be treated with extreme caution. It is strongly recommended that one use harm reduction practices if choosing to use this substance.

Pentedrone is a a molecule of the substituted cathinone chemical class. Substituted cathinones refer to a class of molecules which are principally constituted of a phenethylamine core with an alkyl group attached to the alpha carbon and an oxygen group attached to the beta carbon. They are also known as the beta-ketone (double-bonded oxygen to the β-carbon) analogs of amphetamines. Pentedrone is the a-pentyl beta-keto analog of methamphetamine.

Of general note, the cathinone backbone can be modified in three different places to create hundreds of possible compounds, which include substituents on the aromatic ring, the alpha carbon, and the amine group


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